I just started experiencing this problem last week. I'll be working (on a very light scene, low polys, etc) and my screen will go black and the GPU fan kicks into high gear. I then have to do a force shut down. It's happened 4 times just today....
Reading this brief thread, I'm not convinced Enscape is the problem - but I do believe it's the trigger.
I've owned my new Boxx for about 45 days, and everything has performed flawlessly. I've not added any new software, updated drivers, etc. My spec has remained exactly the same. There's been no Windows10 updates for at least several weeks.
Spec:
(2) Xeon Gold 6226R 2.9GHz
128GB RAM
RTX8000
With that kind of horsepower we can eliminate the GPU or any part of the system becoming overburdened. Everything points to a hardware failure of some kind - most likely in the GPU itself. Software doesn't just magically start causing crashes if absolutely nothing gets updated or changed. However, Enscape has always been running during the black outs, but that doesn't mean Enscape is at fault. Enscape, more than any other process, is going to heat up the GPU. If there's any kind of failure (like eroding or not enough thermal paste), that increased heat will likely trigger the crash.
I'm working the rest of the day on stuff that doesn't require Enscape. Let's see if I have another crash. I'll report back what I find out for anyone else in the future that might experience the same issue.
By the way, Boxx customer service has been excellent. They are ready to replace my RTX8000 immediately to eliminate that as a possible cause....